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KMID : 1039620210110050345
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Korean Journal of Family Practice
2021 Volume.11 No. 5 p.345 ~ p.351
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Association between Muscle Mass Deficits and the Non-Alcoholic Fatty Liver Disease Fibrosis Score in Adults without Central Obesity
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Shim Ye-Na
Choi Hee-Jeong
Jung Dong
Jo Min-So
Oh Han-Jin
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Abstract
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Background: The non-alcoholic fatty liver disease fibrosis score (NFS) is used to determine the direction of treatment by predicting the degree of liverfibrosis in non-alcoholic fatty liver disease (NAFLD). Muscles are the main target organs for insulin, and sarcopenia is associated with the occurrenceof metabolic and cardiovascular diseases. In this study, we investigated the association between muscle mass deficits (MMDs), estimated bybioelectrical impedance analysis (BIA), and the NFS in adults without central obesity.
Methods: Data were collected from 3,704 adults who had visited health promotion centers. Partial correlation analysis was performed to identify thevariables associated with the NFS. Multivariate linear regression analysis was performed to identify the determinants of the NFS. Logistic regressionanalyses were used to estimate the odds ratios for intermediate to high NFS (≥-1.5), according to the MMD groups. Univariate analysis of variancewas used to estimate the corrected means of MMD, according to the NFS groups.
Results: NFS was positively correlated with MMD after adjusting for sex and waist circumference (r=0.033, P<0.05). MMD was positively associated withNFS after adjusting for sex, waist circumference, MMD and other variables in the regression model (R2=0.111). The odds ratios for intermediate tohigh NFS (≥-1.5) increased with the increasing MMD grade after adjusting for age, sex, waist circumference, lifestyle factors, and other variables.
Conclusion: BIA estimates of MMDs in adults without central obesity showed a positive correlation with the NFS. Hence, MMD was identified as a factordetermining the NFS. This suggests that MMD is a predictor of the progression of fibrosis in patients with NAFLD but without central obesity.
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KEYWORD
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Non-Alcoholic Fatty Liver Disease, Muscle, Sarcopenia, Central obesity
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